opentargets-mcp by openpharma-org - MCP Server

Unofficial Open Targets MCP Server

Model Context Protocol server for accessing Open Targets platform data for gene-drug-disease associations research.

{
  "mcpServers": {
    "opentargets-server": {
      "command": "node",
      "args": ["/path/to/opentargets-mcp-server/build/index.js"]
    }
  }
}

Single unified tool with 6 methods via the method parameter:

Search genes by symbol, name, or description.

{ "method": "search_targets", "query": "BRCA1", "size": 10 }

Search diseases by name or synonym.

{ "method": "search_diseases", "query": "breast cancer", "size": 10 }

Get associations with evidence scores. Provide either targetId or diseaseId.

{ "method": "get_target_disease_associations", "targetId": "ENSG00000012048", "size": 10 }

{ "method": "get_target_disease_associations", "diseaseId": "EFO_0000305", "size": 10 }

Get prioritized therapeutic targets for a disease.

{ "method": "get_disease_targets_summary", "diseaseId": "EFO_0000305", "size": 20 }

Comprehensive gene/protein information.

{ "method": "get_target_details", "id": "ENSG00000012048" }

Comprehensive disease information.

{ "method": "get_disease_details", "id": "EFO_0000305" }